Publications of LDGH Members


  • Magalhães WCS, Araujo NM, Leal TP, Araujo GS, Viriato PJS, Kehdy FS, Costa GN,Barreto ML, Horta BL, Lima-Costa MF, Pereira AC, Tarazona-Santos E, Rodrigues MR. Brazilian EPIGEN Consortium. EPIGEN-Brazil Initiative resources: a Latin American imputation panel and the Scientific Workflow. Genome Res. 2018. 28(7):1090-1095.

  • Harris DN, Song W, Shetty AC, Levano KS, Cáceres O, Padilla C, Borda V, Tarazona D, Trujillo O, Sanchez C, Kessler MD, Galarza M, Capristano S, Montejo H, Flores-Villanueva PO, Tarazona-Santos E, O'Connor TD, Guio H. Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6526-E6535.

  • Rodrigues-Soares F, Kehdy FSG, Sampaio-Coelho J, Andrade PXC, Céspedes-Garro C, Zolini C, Aquino MM, Barreto ML, Horta BL, Lima-Costa MF, Pereira AC, LLerena A, Tarazona-Santos E. Genetic structure of pharmacogenetic biomarkers in Brazil inferred from a systematic review and population-based cohorts: a RIBEF/EPIGEN-Brazil initiative. Pharmacogenomics J. 2018 May 1. PubMed PMID: 29713005.

  • Silva TM, Fiaccone RL, Kehdy FSG, Tarazona-Santos E, Rodrigues LC, Costa GNO, Figueiredo CA, Alcantara-Neves, NM, Barreto ML. Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population. Population Health. 2018 April (4);301-306. Access. 

  • Fonseca PAS, Leal TP, Santos FC, Gouveia MH, Id-Lahoucine S, Rosse IC, Ventura RV, Bruneli FAT, Machado MA, Peixoto MGCD, Tarazona-Santos E, Carvalho MRS. Reducing cryptic relatedness in genomic data sets via a central node exclusion algorithm. Mol Ecol Resour. 2018 May;18(3):435-447.

  • Torres KCL, Rezende VB, Lima-Silva ML, Santos LJS, Costa CG, Mambrini JVM, Peixoto SV, Tarazona-Santos E, Martins Filho OA, Lima-Costa MF, Teixeira-Carvalho A. Immune senescence and biomarkers profile of Bambuí aged population-based cohort. Exp Gerontol. 2018 Mar;103:47-56.



  •  Rahbari R, Zuccherato LW, Tischler G, Chihota B, Ozturk H, Saleem S, Tarazona-Santos E, Machado LR, Hollox EJ. Understanding the Genomic Structure of Copy-Number Variation of the Low-Affinity Fcγ Receptor Region Allows Confirmation of the Association of FCGR3B Deletion with Rheumatoid Arthritis. Hum Mutat. 2017 Apr;38(4):390-399. 2017 Feb 15. PubMed PMID: 27995740.
  • Marques CR, Costa GN, da Silva TM, Oliveira P, Cruz AA, Alcantara-Neves NM, Fiaccone RL, Horta BL, Hartwig FP, Burchard EG, Pino-Yanes M, Rodrigues LC, Lima-Costa MF, Pereira AC, Gouveia MH, Sant Anna HP, Tarazona-Santos E, Lima Barreto M, Figueiredo CA. Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children. Eur J Hum Genet. 2017 Apr;25(4):439-445. Jan 25. PubMed PMID: 28120837

  • Zuccherato LW, Schneider S, Tarazona-Santos E, Hardwick RJ, Berg DE, Bogle H, Gouveia MH, Machado LR, Machado M, Rodrigues-Soares F, Soares-Souza GB, Togni DL, Zamudio R, Gilman RH, Duarte D, Hollox EJ, Rodrigues MR. Population genetics of immune-related multilocus copy number variation in Native Americans. J R Soc Interface. 2017 Mar;14(128).  PubMed PMID: 28356540

  •  Lima-Costa MF, Melo Mambrini JV, Lima Torres KC, Peixoto SV, de Oliveira C, Tarazona-Santos E, Teixeira-Carvalho A, Martins-Filho OA. Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. Exp Gerontol. 2017 Nov PubMed PMID: 28803133.

  • Torres KCL, Rezende VB, Lima-Silva ML, Santos LJS, Costa CG, Mambrini JVM, Peixoto SV, Tarazona-Santos E, Martins Filho OA, Lima-Costa MF, Teixeira-Carvalho A. Immune senescence and biomarkers profile of Bambuí aged population-based cohort. Exp Gerontol.  2017 Dec 14. PubMed PMID: 29247791.

  • Fonseca PAS, Leal TP, Santos FC, Gouveia MH, Id-Lahoucine S, Rosse IC, Ventura RV, Bruneli FAT, Machado MA, Peixoto MGCD, Tarazona-Santos E, Carvalho MRS. Reducing cryptic relatedness in genomic data sets via a central node exclusion algorithm. Mol Ecol Resour. 2017 Dec 22 PubMed PMID: 29271609.



  • Lima-Costa MF, Mambrini JV, Leite ML, Peixoto SV, Firmo JO, Loyola Filho AI, Gouveia MH, Leal TP, Pereira AC, Macinko J, Tarazona-Santos E. Socioeconomic Position, But Not African Genomic Ancestry, Is Associated With Blood Pressure in the Bambui-Epigen (Brazil) Cohort Study of Aging. Hypertension. 2016 Feb;67(2):349-55. Epub 2015 Dec 28. PubMed PMID: 26711733.
  • Lima-Costa MF, Macinko J, Mambrini JV, Peixoto SV, Pereira AC, Tarazona-Santos E, Ribeiro AL. Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. PLoS Negl Trop Dis. 2016 May 16;10(5):e0004724. eCollection 2016 May. PubMed PMID: 27182885.

  • Sosa-Macías M, Teran E, Waters W, Fors MM, Altamirano C, Jung-Cook H, Galaviz-Hernández C, López-López M, Remírez D, Moya GE, Hernández F, Fariñas H, Ramírez R, Céspedes-Garro C, Tarazona-Santos E, LLerena A. Pharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America. Pharmacogenomics. 2016 Oct 28. PubMed PMID: 27790935



  • Kehdy FS, Gouveia MH, Machado M, Magalhães WC, Horimoto AR, Horta BL, Moreira RG, Leal TP, Scliar MO, Soares-Souza GB, Rodrigues-Soares F, Araújo GS, Zamudio R, Sant Anna HP, Santos HC, Duarte NE, Fiaccone RL, Figueiredo CA, Silva TM, Costa GN, Beleza S, Berg DE, Cabrera L, Debortoli G, Duarte D, Ghirotto S, Gilman RH, Gonçalves VF, Marrero AR, Muniz YC, Weissensteiner H, Yeager M, Rodrigues LC, Barreto ML, Lima-Costa MF, Pereira AC, Rodrigues MR, Tarazona-Santos E; Brazilian EPIGEN Project Consortium. Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc Natl Acad Sci U S A. 112(28):8696-701. PubMed PMID: 26124090.

  •  Lima-Costa MF, Rodrigues LC, Barreto ML, Gouveia M, Horta BL, Mambrini J, Kehdy FS, Pereira A, Rodrigues-Soares F, Victora CG, Tarazona-Santos E; Epigen-Brazil group. Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative). Sci Rep. 5:9812. PubMed PMID: 25913126.

  • Zamudio R, Pereira L, Rocha CD, Berg DE, Muniz-Queiroz T, Sant Anna HP, Cabrera L, Combe JM, Herrera P, Jahuira MH, Leão FB, Lyon F, Prado WA, Rodrigues  MR, Rodrigues-Soares F, Santolalla ML, Zolini C, Silva AM, Gilman RH, Tarazona-Santos E, Kehdy FS. Population, Epidemiological, and Functional Genetics of Gastric Cancer Candidate Genes in Peruvians with Predominant Amerindian Ancestry. Dig Dis Sci. PubMed PMID: 26391267.

  • Santos HC, Horimoto AV, Tarazona-Santos E, Rodrigues-Soares F, Barreto ML, Horta BL, Lima-Costa MF, Gouveia MH, Machado M, Silva TM, Sanches JM, Esteban N, Magalhaes WC, Rodrigues MR, Kehdy FS, Pereira AC. A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set. Eur J Hum Genet. PubMed PMID: 26395555.

  • Sosa-Macias M, Moya GE, LLerena A, Ramírez R, Terán E, Peñas-LLedó EM, Tarazona-Santos E, Galaviz-Hernández C, Céspedes-Garro C, Acosta H. Population pharmacogenetics of Ibero-Latinoamerican populations (MESTIFAR 2014). Pharmacogenomics. 16(7):673-6. PubMed PMID: 25929854.

  • Araujo GS, Lima LHC, Schneider S, Leal TP, da Silva APC, Vaz de Melo POS, Tarazona-Santos E, Scliar MO, Rodrigues MR. Integrating, summarizing, and visualizing GWAS-hits and human diversity with DANCE (Disease ANCEstry Networks). Bioinformatics. 2016 Apr 15;32(8):1247-9. Dec 15. PubMed PMID: 26673785.

  • Costa GN, Dudbridge F, Fiaccone RL, Silva TM, Conceicao JS, Strina A, Figueiredo CA, Magalhaes WCS, Rodrigues MR, Gouveia M, Kehdy F, Horimoto A, Lessa-Horta B, Burchard E, Pino-Yanes M, Del-Rio-Navarro B, Romieu I, Hancock D, London S, Lima-Costa MF, Pereira A, Tarazona-Santos E, Rodrigues LC, Barreto M. A Genome-wide association study of asthma symptoms in Latin American children. BMC Genet. 2015 Dec 3;16:141. PubMed PMID: 26635092.

  • Lima-Costa MF, Macinko J, Mambrini JM, Cesar CC, Peixoto SV, Magalhaes WCS, Lessa-Horta B, Barreto M, Castro-Costa E, Firmo JO, Proietti FA, Leal TP, Rodrigues MR, Pereira A, Tarazona-Santos E. Genomic ancestry, self-rated health and its association with mortality in an admixed population: 10 year follow-up of the Bambui-Epigen (Brazil) Cohort Study of Ageing. PLoS One. 2015 Dec 17;10(12):e0144456. PubMed PMID: 26680774

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